Collagen Wound Dressing

100% bovine collagen supports wound healing and has favorable tissue affinity and excellent biocompatibility.

A porous matrix of cross-linked bovine collagen makes up LUOFUCON^® Collagen Wound Dressing. The LUOFUCON^® Collagen Wound Dressing is a sterile, single-use wound dressing that is white or off-white, malleable, absorbent, and biodegradable.

When the wound dressing absorbs wound exudate or sterile water, LUOFUCON^® Collagen Wound Dressing transforms into a soft, conformable gel sheet, maintains a moist wound environment, to protect the wound and support natural healing.

LUOFUCON^® Collagen Wound Dressing may be applied directly to the wound as a primary dressing or may be used in conjunction with other acceptable secondary dressings. The dressing may be used in numerous layers and can be precisely trimmed to fit the size of the wound.

100% Type I collagen of bovine, no fillers.

Cover the wound to form a physical barrier and protect the wound from external environment.

Sufficient mechanical strength for easy application.

Strong absorption capacity, can absorb 38 times of its own weight.

Gel after absorption and maintains a wet environment conducive to wound healing.

Original triple helix structure makes it have good biocompatibility.

LUOFUCON^® Collagen Wound Dressing offers a greater collagen content than comparable products since it is composed 100% type I bovine collagen.

LUOFUCON^® Collagen Wound Dressing has high biocompatibility, and the cells bridged on the dressing have a superior growth trend, according to the findings of cell proliferation tests for the 1st, 4th and 7th days.

Higher cell densities of 3T3 fibroblasts are observed in the dressing due to the attached scaffolds for cell proliferation and migration. 

Green fluorescence - Active cells
Red fluorescence - Inactive cells

LUOFUCON^® Collagen Wound Dressing has good mechanical strength, which provides easy application for medical professional.

LUOFUCON^® Collagen Wound Dressing softly treats the wound bed and wound edge because it is mildly acidic, which is closer to the pH value of skin.

LUOFUCON^® Collagen Wound Dressing has strong weight capacity of absorption. It has a significant capacity for absorption, which is helpful in preserving the moist environment for wound healing and reduces the danger of maceration.

The original triple-helix structure of this protein, which is the most prevalent in animal tissues, makes it useful for supporting wound healing.

 Collagen

Collagen is the unique, triple helix protein molecule, which forms the major part of the extracellular dermal matrix (ECM), together with the glycosaminoglycans, proteoglycans, laminin, fibronectin, elastin and cellular components.

Collagen is the most abundant protein in animal tissues and accounts for 80%-90% of the dry weight of the dermis. Mainly produced by fibroblasts, at least 29 genetically distinct collagens have currently been identified, with six of these being present in the skin. Collagen type I comprises approximately 90% of collagen in the skin. Type I and III are important for wound healing.

What is the collagen ?

Collagen type I molecular structure image retrieved from online database on December 3 2018, from http://www.harbormedtech.com/bridge 

Collagen plays an important role in each of these phases of wound healing due to its chemotactic role. It attracts cells such as fibroblasts and keratinocytes to the wound. This encourages angiogenesis and reepithelialisation.

A chronic wound is stalled at one of these healing stages. This usually occurs during the inflammatory phase and is linked to elevated levels of matrix metalloproteinases (MMPs) in the wound. In normal wound healing, proteases such as MMPs are attracted to the wound during the inflammatory phase and have an important role in breaking down unhealthy ECM so that new tissue forms. However, when MMPs are present in a wound at elevated levels for a prolonged period of time, this results in the destruction of healthy ECM, which is associated with delayed wound healing and an increase in wound size.

When the excess of MMPs is not balanced by normal physiological processes, alternative methods are required to reduce protease levels in the wound. This suggests a role for dressings containing collagen in the management of wounds where healing is stalled.

Role of collagen in wound healing

The use of collagen dressings may seem attractive in view of their functions to:

Collagen dressings in wound management

Inhibit or deactivate MMPs

Aid in the uptake and bioavailability of fibronectin

Help to preserve leukocytes, macrophages, fibroblasts, and epithelial cells

Assist in the maintenance of the chemical and thermostatic microenvironment of the wound

Increase fibroblast production and permeation

Advantages about LUOFUCON^® Collagen Wound Dressing

The dressing, which falls under the category of permanent contact device, is non-pyrogenic, super conformance, entirely absorbable, and simple to use. 

Dressings are suitable for use under compression under proper supervision by a healthcare professional.

It serves as a porous scaffold for cell proliferation and migration and may be used as a hemostatic dressing for surface wounds.

The product's strength and enzyme resistance are increased without the use of chemical additives and with the aid of safe cross-linking technology.

The dressing, which falls under the category of permanent contact device, is non-pyrogenic, super conformance, entirely absorbable, and simple to use. 

LUOFUCON^® Collagen Wound Dressing has an excellent and homogeneous fiber network structure, which makes it have high biocompatibility and is helpful to aiding wound healing, as is seen from the electron microscope image. 

LUOFUCON^® Collagen Wound Dressingis intended for the management of wounds including: 

Indications

Full thickness and partial thickness wounds
Pressure ulcers
Venous ulcers
Ulcers caused by mixed vascular etiologies
Diabetic ulcers
Partial thickness burns
Donor sites and other bleeding surface wounds
Abrasions
Traumatic wounds healing by secondary intention
Dehisced surgical incisions

Patients who are sensitive to bovine collagen, those with third-degree burns, or wounds that are infected actively should not use collagen wound dressing.

Contraindications

for using
Collagen Wound Dressing

Do not use with uncontrolled clinical infection.

Tips

Do not use if the package seal is broken.

Do not use dressing after expiration date.
 

Discard device if mishandling has caused possible damage or contamination.
 

Discard all open and unused portions of dressing.
 

Do not re-sterilize. 
 

Do not reuse.
 

Discontinue use and contact a physician if any adverse reactions and abnormal symptoms occur.

[1] Rangaraj A ,  Harding K ,  Leaper D . Role of collagen in wound management[J]. Wounds Uk, 2011.
[2] Riccio M . Safety and Efficacy of Collagen-Based Biological Dressings in the Management of Chronic Superficial Skin Wounds in Non-Complex Trauma: A Post-Marketing Surveillance Study[J]. Trauma Care, 2021, 1.

Reference